Cytoprotection in gastroesophageal reflux disease and prospects for the use of cytoprotective agents

The analysis of publications is devoted to the problem treatment and prevention gastroesophageal reflux disease with use cytoprotectors. Special attention paid Gastrotop, new complex plant origin. Gastrotop (Еrвоzета S.p.A, San Marino) a medication cytoprotective action, containing Mucosave CG, standardized polysaccharides from stems Indian prickly pear (Opuntia ficus‑indica, 33.5%), leaves European olive (Olea europaea, 24.0%); mixture sodium alginate salts (sodium — 50 mg, potassium bicarbonate 10 calcium carbonate mg), an extract Malva sylvestris L. mg. Its action aimed at increasing protection esophageal gastroduodenal mucosa irritating effects hydrochloric acid, pepsin, detergent effect bile during by means formation strong mucoadhesive biofilm on walls esophagus. authors present results randomized, double‑blind, controlled clinical trial evaluating efficacy safety preparation based alginate/sodium in combination extracts obtained Opuntia ficus indica Olea europaea related polyphenols dynamics GERD symptoms. It has been established that well tolerated effective controlling symptoms associated mild manifestations. demonstrated perspective administration as part cases when it’s necessary cancel antisecretory drugs (in particular, proton pump inhibitors PPIs), for example, before assessing persistence Helicobacter pylori infection or purpose monitoring eradication effectiveness. cytoprotectors promotes reduction incidence possible complications, caused long‑term PPIs’ use.